Nanoparticulate drug delivery system has emerged as one of the most propitious field in different disease treatments. During the past decade, the importance of polymeric drug delivery systems has grown exponentially. In this context, Hyaluronic Acid (HA), a natural acidic mucopolysaccharide is a widely used polymer for fabricating ‘nanoparticles’. Because of biocompatibility, wide biomedical applications and utility for sustained drug release, it has been the centre of focus for developing drug-loaded nanoparticles for different therapy. Such HA based nanoparticles have also been used to develop the site specific therapy as well as diagnostics. These drug-loaded nanoparticles extravasate through the tumour vasculature, delivering their payload into the cells by the enhanced permeability and retention (EPR) effect, thereby increasing their therapeutic effect. This review shortly outlines the uses and possibilities of hyaluronic acid in conjugation with various polymers and drugs. Moreover the modern applications in different fields of nanoparticulate drug delivery also focussed here.
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